Landmark Publication on Vitamin C for COVID-19

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Despite what the mainstream media desire you to believe, numerous are beginning to recognize the fact, which is that both vitamin C (ascorbic acid) and vitamin D have a huge quantity of research study revealing they offer essential immune function improvements, which your immune function is your frontline defense versus all health problem, consisting of COVID-19

As reported in the paper “Ideal Nutritional Status for a Well-Functioning Body Immune System Is an Essential Element to Safeguard Versus Viral Infections,” released April 23, 2020: 1

” The function nutrition plays in supporting the body immune system is reputable. A wealth of mechanistic and scientific information reveal that vitamins, consisting of vitamins A, B6, B12, C, D, E, and folate; micronutrient, consisting of zinc, iron, selenium, magnesium, and copper; and the omega-3 fats eicosapentaenoic acid and docosahexaenoic acid play essential and complementary functions in supporting the body immune system.

Insufficient consumption and status of these nutrients are extensive, causing a decline in resistance to infections and as an effect a boost in illness concern.”

High-Dose Vitamin C Functions As an Antiviral Drug

As described in the video above by Dr. Andrew Saul, editor-in-chief of the Orthomolecular Medication News Service, at very high dosages, vitamin C really serves as an antiviral drug, successfully suspending infections.

His Tokyo discussion, “Orthomolecular Medication and Coronavirus Illness: Historic Basis for Nutritional Treatment,” highlights the truth that when utilized as a treatment, high dosages of vitamin C– typically 1,000 times more than the U.S. Recommended Dietary Allowance (RDA)– are required.

It’s a foundation of medical science that dosage impacts treatment result, however this property isn’t accepted when it concerns vitamin treatment the method it is with drug treatment. Many vitamin C research study has actually utilized insufficient, low dosages, which do not result in scientific outcomes.

” The medical literature has actually overlooked over 80 years of lab and scientific research studies on high-dose ascorbate treatment,” Saul notes, including that while it’s extensively accepted that vitamin C is useful in combating health problem, debate exists over to what degree. “Moderate amounts offer efficient avoidance,” he states, while “big amounts are healing.”

Landmark Paper Puts Vitamin C on the COVID-19 Treatment Map

While health authorities and traditional media have actually overlooked, if not straight-out opposed, using vitamin C and other supplements in the treatment of COVID-19, mentioning absence of scientific proof, we now have a landmark evaluation 2 advising using vitamin C as an adjunctive treatment for breathing infections, sepsis and COVID-19

The evaluation, 3 released December 7, 2020, in the journal Nutrients, was co-written by Dr. Paul Marik who, in 2017, established a groundbreaking vitamin C-based treatment for sepsis Marik is now directing the Cutting edge COVID-19 Crucial Care Alliance, 4 which has actually established an extremely effective treatment for COVID-19

The COVID-19 procedure was at first called MATHEMATICS+ (an acronym based upon the essential parts of the treatment), however after a number of tweaks and updates, the prophylaxis and early outpatient treatment procedure is now called I-MASK+ 5 while the healthcare facility treatment has actually been relabelled I-MATH+, 6 due to the addition of the drug Ivermectin. Vitamin C stays a main element of this treatment, however.

( The 2 procedures 7, 8 are readily available for download on the FLCCC Alliance site in several languages. The scientific and clinical reasoning for the I-MATH+ healthcare facility procedure has actually likewise been peer-reviewed and was released in the Journal of Intensive Care Medication 9 in mid-December 2020.) As described in the Nutrients evaluate abstract: 10

” There are minimal tested treatments for COVID-19 Vitamin C’s anti-oxidant, anti-inflammatory and immunomodulating impacts make it a prospective healing prospect, both for the avoidance and amelioration of COVID-19 infection, and as an adjunctive treatment in the important care of COVID-19

This literature evaluation concentrates on vitamin C shortage in breathing infections, consisting of COVID-19, and the systems of action in contagious illness, consisting of assistance of the tension reaction, its function in avoiding and dealing with colds and pneumonia, and its function in dealing with sepsis and COVID-19

The proof to date shows that oral vitamin C (2-8 g/day) might lower the occurrence and period of breathing infections and intravenous vitamin C (6-24 g/day) has actually been revealed to lower death, extensive care system (ICU) and healthcare facility stays, and time on mechanical ventilation for serious breathing infections …

Provided the beneficial security profile and low expense of vitamin C, and the frequency of vitamin C shortage in breathing infections, it might be beneficial screening clients’ vitamin C status and treating them appropriately with intravenous administration within ICUs and oral administration in hospitalized individuals with COVID-19″

Global Vitamin C Project Launched

In a December 16, 2020, action alert,11 Rob Verkerk, Ph.D., creator and clinical director of the Alliance for Natural Health, revealed the launch of a global vitamin C project12 in reaction to the landmark evaluation, which “puts all the arguments and science in one, cool location.”

As kept in mind by Verkerk, there are a number of factors to take additional vitamin C. First, your body can not make it. Second, many people do not get adequate quantities from their diet plan and, 3rd, your body’s requirement for vitamin C can increase 10- fold whenever your body immune system is challenged by an infection, illness or physical injury.

In truth, the Nutrients evaluation13 mentions that it prevails for hospitalized clients to have obvious vitamin C shortage, specified as a blood level at or listed below 11 µmol/ L. This is especially real for older clients and those hospitalized for breathing infections.

According to the authors, “Vitamin C concentrations are 3 to 10 times greater in the adrenal glands than in any other organ. It is launched from the adrenal cortex under conditions of physiological tension (ACTH stimulation), consisting of viral direct exposure, raising plasma levels fivefold.” In his action alert, Verkerk notes: 14

” Taking vitamin C as a preventative and after that, upping your consumption if you’re contaminated, is a no brainer. So is utilizing vitamin C intravenously for those with intense breathing infections, or sepsis, in important care.

A lot so, that we argue– offered the now readily available proof– that physicians and other health experts who prevent suggestions on vitamin C in relation to COVID illness avoidance and treatment, ought to be thought about clinically irresponsible …

There is adequate proof to reveal that supplements like zinc, vitamin C, and vitamin D can assist avoid and deal with COVID-19, however we’re avoided from finding out about these advantages by the federal government.

Due to the fact that supplements are not, and can never ever end up being, FDA-approved, they can not declare to have an influence on illness, even when we understand they can. This rubbish needs to stop.”

How Vitamin C Functions

As discussed, the Nutrients evaluation15 information vitamin C’s systems of action and how it assists in cases of contagious illness, consisting of the acute rhinitis, pneumonia, sepsis and COVID-19 For beginners, vitamin C has the following standard residential or commercial properties:

  • Anti-inflammatory
  • Immunomodulatory
  • Antioxidant
  • Antithrombotic
  • Antiviral

Beneficial antiviral impacts use to both the inherent and adaptive body immune systems. When you have an infection, vitamin C enhances your immune function in part by promoting the advancement and maturation of T-lymphocytes, a kind of leukocyte that is a vital part of your body immune system.

Phagocytes, immune cells that eliminate pathogenic microorganisms, are likewise able to take in oxidized vitamin C and regrow it to ascorbic acid. With regard to COVID-19 particularly, vitamin C: 16

Assists downregulate inflammatory cytokines, therefore decreasing the danger of a cytokine storm. It likewise decreases swelling through the activation of NF-κB and by increasing superoxide dismutase, catalase and glutathione. Epigenetically, vitamin C controls genes associated with the upregulation of antioxidant proteins and downregulation of proinflammatory cytokines

Safeguards your endothelium from oxidant injury

Assists repair work broken tissues

Upregulates expression of Type-1 interferons, your main antiviral defense reaction, which SARS-CoV-2 downregulates

Removes ACE2 upregulation caused by IL-7. This is especially notable, as the ACE2 receptor is the entry point for SARS-CoV-2 (the infection’ spike protein binds to ACE2)

Seems an effective inhibitor of Mpro, a crucial protease (enzyme) in SARS-CoV-2 that triggers viral nonstructural proteins

Manages neutrophil extracellular trap development (NETosis), a maladaptive reaction that leads to tissue damage and organ failure

Improves lung epithelial barrier function in an animal design of sepsis by promoting epigenetic and transcriptional expression of protein-channels at the alveolar capillary membrane that manage alveolar fluid clearance

Moderates the adrenocortical tension reaction, especially in sepsis

The chart listed below, from the Nutrients evaluation, highlights the essential methods which vitamin C ameliorates the pathology seen in COVID-19

vitamin C ameliorates the pathology seen in COVID-19

Nebulized Peroxide May Be Even Much Better

The gorgeous graphic above makes it actually clear that a person of the main manner ins which vitamin C works is through the generation of reactive oxygen types. Think what the main one is? If you thought hydrogen peroxide offer yourself a high 5!

It is extremely most likely that the peroxide forms an extremely effective signaling function that promotes the body immune system to beat whatever viral hazard it is exposed to. This is among the reasons that nebulized peroxide is my outright preferred intervention for intense viral health problems. It is extremely efficient, affordable and has no adverse effects when utilized at the really low dosages advised (0.1%, which is 30 times less focused than routine pharmacy 3% peroxide).

My video listed below goes over the information of how you can utilize this treatment. The secret is to have your nebulizer currently acquired and prepared to go so that it is locked and filled and you do not need to go out and acquire anything if you or a liked one gets ill. You can still utilize vitamin C with the peroxide, as they likely have an effective synergy and utilize various complimentary systems.

Considering That you are not utilizing complete strength 3% peroxide and diluting it by 30 to 50 times, it is not likely the stabilizers will provide an issue, however to be safe, it is best to utilize FOOD-GRADE peroxide. Likewise, do not dilute it with plain water as the absence of electrolytes in the water can harm your lungs if you nebulize it. Rather, utilize saline or include a percentage of salt to the water to remove this danger.

peroxide dilution charts

Medical Proof

The Nutrients evaluation17 likewise consists of scientific proof for the function of vitamin C in COVID-19, keeping in mind that early oral supplements may assist avoid a moderate case from becoming something more severe. In clients with important signs, intravenous administration of vitamin C has actually been revealed to accelerate healing, decreasing both ICU stays and death.

Remarkably, vitamin C shortage and COVID-19 share a lot of the exact same danger aspects, consisting of male gender, darker skin, older age and comorbidities such as diabetes, hypertension and COPD. All of these subgroups are at increased danger for serious COVID-19 and, according to the authors, all “have actually likewise been revealed to have lower serum vitamin C levels.”

Discussing the scientific proof supporting using vitamin C in the treatment of COVID-19, the authors compose: 18

” There are presently 45 trials signed up on examining vitamin C with or without other treatments for COVID-19 In the very first RCT to check the worth of vitamin C in seriously ill COVID-19 clients, 54 aerated clients in Wuhan, China, were treated with a placebo (sterilized water) or intravenous vitamin C at a dosage of 24 g/day for 7 days …

The more seriously ill clients with COUCH [sequential organ failure assessment] ratings ≥ 3 in the vitamin C group displayed a decrease in 28- day death: 18% versus 50% in univariate survival analysis (Figure 2). No study-related negative occasions were reported.”

Figure 2 listed below, from variation 1 of the research study,19 “High-Dose Vitamin C Infusion for the Treatment of Seriously Ill COVID-19,” published on the preprint server Research study Square August 10, 2020 (upgraded September 23, at which point it was relabelled20), reveals the 28- day death rates in between seriously ill COVID-19 clients offered high-dose IV vitamin C (HDIVC) compared to those offered a placebo.

28 day mortality rates

The Nutrient evaluation likewise sums up findings from other COVID-19 trials utilizing vitamin C, along with a couple of case reports: 21

” In the UK, the Chelsea and Westminster healthcare facility ICU, where adult ICU clients were administered 1 g of intravenous vitamin C every 12 h together with anticoagulants, has actually reported 29% death, compared to the average 41% reported by the Intensive Care National Audit and Research Study Centre (ICNARC) for all UK ICUs …

The Frontline COVID-19 Crucial Care Professional Group (FLCCC), a group of emergency situation medication specialists, have actually reported that, with the integrated usage of 6 g/day intravenous vitamin C (1.5 g every 6 h), plus steroids and anticoagulants, death was 5% in 2 ICUs in the United States (United Memorial Healthcare Facility in Houston, Texas, and Norfolk General Healthcare Facility in Norfolk, Virginia), the most affordable death rates in their particular counties.

A case report of 17 COVID-19 clients who were offered 1 g of intravenous vitamin C every 8 h for 3 days reported a death rate of 12% with 18% rates of intubation and mechanical ventilation and a considerable decline in inflammatory markers, consisting of ferritin and D-dimer, and a pattern towards reducing FiO 2 requirements.

Another case of unanticipated healing following high-dose intravenous vitamin C has actually likewise been reported. While these case reports go through confounding and are not prima facie proof of impacts, they do show the expediency of utilizing vitamin C for COVID-19 without any negative impacts reported.”

Just How Much Vitamin C Do You Required?

As detailed in the intro of the Nutrients evaluation,22 primates and people depend on a sufficient supply of vitamin C from vegetables and fruits. Gorillas require 4.5 grams a day, while smaller sized primates weighing around 7.5 kilos require about 600 mg daily. This offers us an idea regarding what the human requirement may be, and it’s a fair bit greater than the day-to-day advised consumption. According to the authors: 23

” The EU Average Requirement of 90 mg/day for males and 80 mg/day for females is to preserve a typical plasma level of 50 µmol/ L, which is the mean plasma level in UK grownups. This suffices to avoid scurvy however might be insufficient when an individual is under viral direct exposure and physiological tension.

A skilled panel in cooperation with the Swiss Society of Nutrition advised that everybody supplement with 200 mg ‘to fill the nutrient space for the basic population and particularly for the grownups age 65 and older. This supplement is targeted to reinforce the body immune system.’ The Linus Pauling Institute suggests 400 mg for older grownups (>>50 years of ages).

Pharmacokinetic research studies in healthy volunteers support a 200- mg daily dosage to produce a plasma level of circa 70 to 90 µmol/ L. Total plasma saturation takes place in between 1 g day-to-day and 3 g every 4 hours, being the greatest endured oral dosage, offering an anticipated peak plasma concentration of circa 220 µmol/ L.

The exact same dosage offered intravenously raises plasma vitamin C levels roughly significantly. Greater consumptions of vitamin C are most likely to be required throughout viral infections with 2– 3 g/day needed to preserve typical plasma levels in between 60 and 80 µmol/ L. Whether greater plasma levels have fringe benefit is yet to be figured out, however would follow the outcomes of the scientific trials talked about in this evaluation.”

While high-dose vitamin C programs generally require intravenous administration, if dealing with a viral infection in your home (be it COVID-19 or something else), you might utilize oral liposomal vitamin C, as this permits you to take far greater dosages without triggering loose stools.

You can use up to 100 grams of liposomal vitamin C without issues and get actually high blood levels, comparable to or greater than intravenous vitamin C. I see that as a severe treatment, nevertheless. I dissuade individuals from taking mega dosages of vitamin C regularly if they’re not really ill, due to the fact that it is basically a drug– or a minimum of it works like one.

Saul, who has actually dealt with and advised vitamin C for the majority of his expert life recommends taking “sufficient vitamin C to be symptom-free,” whatever dose that may be. When you’re well, you generally do not require more than the 200 mg to 400 mg advised in the quote above.

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